|The Brain Simulation Platform "Live Papers"|
Authors: Katiuscia Martinello1, Elisabetta Giacalone2, Michele Migliore2, David A. Brown3, and Mala M. Shah1
Author information: 1UCL School of Pharmacy University College London, London WC1N 1AX, UK, 2 Institute of Biophysics, National Research Council, 90146 Palermo, Italy, 3Department of Neuroscience, Physiology and Pharmacology, University College London, London WC1E 6BT, UK.
Corresponding author: Author (Mala M. Shah firstname.lastname@example.org )
Citation: Martinello, K., Giacalone, E., Migliore, M., Brown, D. A., & Shah, M. M. (2019). The subthreshold-active Kv7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals. Communications biology, 2(1), 145.
Data and models: data and models used in the paper are available at the links reported below.
A reduced self-consistent set of files needed to reproduce Fig. 4b,c and d of the paper is available on
The simulations will reproduce functional effects of Km removal in mossy fiber boutons.
The default settings will reproduce control condition in Fig. 4b,c (Single AP) and Fig. 4d (50Hz Train) of the paper, which refer to the last action potential and all action potentials shown in Fig. 3a and Fig. 3d respectively.
HOWTO: Change settings by turning "on" the "Reset/set parameters" switch to run simulation with your own conductance configuration. Set gKM=0.0 or both conductances to 0.0 to reproduce respectively red and blue lines of the Fig. 4b,c,d.
Use the "Single AP/50 Hz Train" switch to simulate a single current injection or a 50Hz current pulses train, respectively.
Turn "on" the "Persistent plot" switch to compare plots of different simulations.