|The Brain Simulation Platform "Live Papers"|
Authors: Sergio M. G. Solinas1,2, Elke Edelmann3,4, Volkmar Leßmann3,4, Michele Migliore1
Author information: 1Istitute of Biophysics, National Research Council, Palermo, Italy, 2 Institute of Neuroinformatics, University of Zurich and ETH Zurich, Zurich, Switzerland, 3Institute of Physiology, Otto-von-Guericke-University, Medical Faculty, Magdeburg, Germany, 4Center for Behavioral Brain Sciences (CBBS), Magdeburg, Germany.
Corresponding author: Michele Migliore ( firstname.lastname@example.org )
Citation: Solinas SMG, Edelmann E, Leßmann V, Migliore M (2019) A kinetic model for Brain-Derived Neurotrophic Factor mediated spike timing-dependent LTP. PLoS Comput Biol 15:e1006975
Model and data: the model and the data used in the paper are available at the links reported in the sections below
A reduced self-consistent set of files needed to reproduce Fig.3A,3B and Fig.4A,4B of the paper is available on
The model shows how the back-propagating action potentials in the oblique dendrites of CA1 neurons collide at the spines with a locally elicited EPSP to trigger the release of a retrograde messenger or Brain-Derived Neurotrophic Factor inducing the late expression of spike timing-dependent plasticity.
HOWTO: Change settings by clicking the "LTP11" or "LTP14" buttons in order to set the default parameters to be used for reproducing the manuscript's figures Fig.3A,3B and Fig.4A,4B respectively. Alternatively you can manually set the "Tstop", "nBPAP" and "nStim" parameters. Once the parameters are set, click the "Run" button to launch the simulation. After the plots are dispayed, you can toggle on/off individual trace visualization by double clicking on trace names in the legend. Finally, you can zoom in by clicking and dragging and zoom out by double clicking inside the plots or by dragging the cursor after positioning it on the x-tick/y-tick axis values.