|The Brain Simulation Platform "Live Papers"|
Authors: John P. McCauley1, Maurice A. Petroccione1, Lianna Y. D’Brant1,2, Gabrielle C. Todd1, Nurat Affinnih1, Justin J. Wisnoski1, Shergil Zahid1, Swasti Shree1,3, Alioscka A. Sousa4,5, Rose M. De Guzman6, Rosanna Migliore7, Alexey Brazhe8,9, Richard D. Leapman5, Alexander Khmaladze2, Alexey Semyanov9,10, Damian G. Zuloaga6, Michele Migliore,7, and Annalisa Scimemi1
Author information: 1Department of Biology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA, 2 Department of Physics, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA, 3 Bethlehem Central High School, 700 Delaware Avenue, Delmar, NY 12054, USA, 4 Federal University of Sao Paulo, Department of Biochemistry, 100 Rua Tres de Maio, Sao Paulo 04044-020, Brazil, 5 National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA, 6 Department of Psychology, SUNY Albany, 1400 Washington Avenue, Albany, NY 12222, USA, 7 Institute of Biophysics, National Research Council, 153 Via Ugo La Malfa, Palermo 90146, Italy, 8 Department of Biophysics, Lomonosov Moscow State University, Leninskie Gory 1/12, Moscow 119234, Russia, 9 Department of Molecular Neurobiology, Institute of Bioorganic Chemistry, Ulitsa Miklukho-Maklaya 16/10, Moscow 117997, Russia, 10Sechenov First Moscow State Medical University, Bolshaya Pirogovskaya Ulitsa 19s1, Moscow 119146, Russia.
Corresponding author: (Annalisa Scimemi email@example.com )
Citation: McCauley et al., Cell Reports 33, 108255, 2020.
Data and models: data and models used in the paper are available at the links reported below.
A reduced self-consistent set of files needed to reproduce Fig. 6c of the paper is available on
After selecting the options corresponding to the modulation of the NMDA receptor weights and the AMPA recovery time, simulation will reproduce the temporal summation of composite glutamatergic EPSPs at the stimulation frequency of 10 Hz (Fig. 6c of the paper).
The simulations were run to mimic glutamatergic EPSPs during the L phase (τrec=10 and wNMDA=0.009, the default settings) and in conditions that mimic the reduced NMDA receptor expression in the D phase (τrec=10 and wNMDA=0.00243, green line), the reduced AMPA EPSP summation during the D phase due to retraction of astrocytic processes (τrec=20 and wNMDA=0.009, yellow line), or both effects at the same time (τrec=20 and wNMDA=0.00243, brown line).
HOWTO: Change settings by turning "on" the "Reset/set parameters" switch to run simulation with your own NMDA and AMPA receptor configuration.
Turn "on" the "Persistent plot" switch to compare plots of different simulations.